New discovery from Cellis team has been published in Cell Communication and Signaling! The paper, “A novel process for transcellular hemoglobin transport from macrophages to cancer cells,” highlights seven years of dedicated research and collaboration, including contributions from the Mossakowski Medical Research Institute – Polish Academy of Sciences (IMDiK PAN).
This study uncovers a previously unknown mechanism where macrophages take up hemoglobin (Hb) independently of the haptoglobin-CD163 pathway and transfer it to cancer cells instead of degrading it. This process, partly mediated by extracellular vesicles, has exciting implications for cancer therapies.
Even more promising, the research demonstrates how macrophages loaded with Hb-anticancer drug conjugates can effectively target and kill cancer cells in vitro, opening new therapeutic possibilities. 🚀
A huge congratulations to all co-authors for their outstanding contributions: Agata Braniewska, Marcin Skórzyński, Zuzanna Sas, Magdalena Długołęcka, Ilona Marszałek, Daria Kurpiel, Marcel Bühler, Damian Strzemecki, Aneta Magiera, Maciej Białasek, Jarosław Walczak, Łukasz Cheda, Michał Komorowski, Tobias Weiss, Małgorzata Czystowska-Kuźmicz, Karina Kwapiszewska, Alberto Boffi, Magdalena Król, and Tomasz Rygiel.
Read the full article here:
#CancerResearch #MacrophageTherapy #Innovation #CellCommunication #IMDiKPAN #Cellis
